Blood-C is a 2011 anime/manga series and 2012 film produced in collaboration by Studio Production I.G and manga creators CLAMP. This is Production I.G's second anime series related to the Blood franchise, the first being Blood+, which aired in 2005–2006. An animated film, Blood-C: The Last Dark was released in Japanese theatres on June 2, 2012.

Blood-C was designed to share only thematic similarities with earlier Blood projects. The series focuses on Saya Kisaragi, an outwardly normal girl who serves as the shrine maiden to a country town; in reality, she is a skilled swordswoman charged by her father to defeat Elder Bairns, monsters who feed on human blood. As her battles grow more desperate and more people she cares for fall victim to the Elder Bairns, Saya begins finding faults in her reality, and eventually uncovers a disturbing truth about herself, the town and her surviving friends. The Elder Bairns were inspired by the Great Old Ones from H. P. Lovecraft's Cthulhu Mythos, and modeled after traditional Japanese monsters.

The show's bloody violence, a stylistic choice following the series' themes, resulted in censorship in Japan and eventual blacklisting in China. Blood-C has received mixed to positive reviews from journalists. There is a Blood-C Wiki.

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