The first Region 1 DVDs were released on March 4, 2008, with a simultaneous release of a single five episode volume and a twenty-five episode box set.
The series was first released to Region 2 DVD in Japan by Aniplex in thirteen volumes. The first volume contained two episodes, and each subsequent volume contained four more. The first volume was released December 21, 2005 and the final on December 29, 2006. All of the volumes have Japanese language tracks with no subtitles. The first Region 1 DVDs were released on March 4, 2008, with a simultaneous release of a single five episode volume and a twenty-five episode box set.
Sony Entertainment began releasing its English adaptation of the series on March 4, 2008. Sony released two versions simultaneously: an individual volume containing the first five episodes, and a six disc special edition set containing the first 25 episodes and several exclusive extras. The second box set, containing the remaining 25 episodes and more extras, was released on October 20, 2009.
Two Sony PlayStation 2 video games have been created that are based on the Blood+ series. Both games are currently only available in Japan and have not been licensed for release in any other countries.
Blood+: One Night Kiss, from Namco Bandai Games and Grasshopper Manufacture, is an Action-adventure game that was originally released on August 30, 2006. Featuring cel-shaded graphics in the same style as Killer7, the game is directed by the CEO of Grasshopper, Goichi Suda. Set in the fictional town of Shikishi, players spend most of the game playing as Saya, occasionally switching to Aoyama, an original character created for the game.
Blood+: Sōyoku no Battle Rondo, from Sony Entertainment, is an adventure game released on July 27, 2006. Set during the year between episodes 32 and 33, after Riku's death, the game alternates between an "Active Demo" section where the player can make decisions that change the story line, and full action sequences where the player, as Saya, fights with her sword to collect chiropteran crystals.
In addition to the two PS2 games, Sony Entertainment released the PSP game Blood+: Final Piece on September 7, 2006. It is an adventure role-playing video game that utilizes animated sequences from the series as well as new footage created specifically for the game. The plot of the game is set during the first season of the series, and features an original story in which Saya, joined by three friends from school, investigates the mystery of her father's disappearance.